

Two minigames played between stages require players to hit their buttons as quickly as possible, with computer-controlled enemies replacing any characters not in play. One life is lost whenever a player's health meter runs out if all lives are lost, the player may continue the game by adding credits within a time limit. Players can also pick up and throw/swing items such as hammers, bowling balls, and mailboxes as melee weapons. Each player has a health meter, which decreases upon being hit by enemies food items can be picked up to replenish it. Two characters standing close to each other can mount a combined attack, such as Homer and Marge holding each other's ankles to roll around the screen and mow down enemies, or Homer placing Lisa on his shoulders so they can strike at two different heights. The characters have distinctive attack styles Homer punches and kicks, Marge swings a vacuum cleaner, Bart wields a skateboard, and Lisa attacks with a jump rope. Controls consist of an eight-way joystick and two buttons to jump and attack. Two different cabinet models were produced: one allowing up to two simultaneous players, each able to choose a character, and another allowing four players with a dedicated position for each character. The Simpsons is a side-scrolling beat 'em up that allows players to join in at any time.

Screenshot from Stage 7 of the game, where Marge battles two "Royd" and one "Rupert" enemies.
